Food allergies in the present circumstance are developing with a rapid speed as a major problem of the society. Food exposure to some common foodstuffs including peanuts or milk can impact adversely on mammal body. Food allergies have contaminated the human organ especially it has grasped the children within its hold.
Studies and researches have brought into forefront that modern hygienic and dietary practices are extremely conscientious in disturbing the natural bacterial composition of human body. In finding out whether gut bacteria has potentiality to prevent food allergies or not, a team conducted by Cathryn Nagler.
They remarkably discovered that the presence of a common class of gut bacteria named as Clostridia has potentiality to protect against food allergies. According to study clostridia can diminish allergens exposure which eventually leads to the prevention of sensitization.
How clostridia affects food allergies
To discover how clostridia can prevent food allergies, researchers have undergone through an investigation process on mice. A germ-free mice and mice treated with antibiotic that symbolizes as newborns are being exposed to peanut allergens. Both groups of mice exhibited a strong immunological response and produced higher levels of antibodies to fight back against peanut allergens than the mice which have induced with normal gut bacteria.
Researchers have proved through the process of reintroduction of another major group of intestinal bacteria named as Bacteroids which unfortunately failed to prevent food allergens and indicated that Clostridia is comprised with unique feature of protecting human body from food allergies.
To identify the protective mechanism of Clostridia bacteria researchers have also undergone through another study concerning cellular and molecular immune reactions to bacteria in the gut. Genetic analysis exposed the fact that clostridia assist natural immune cells to produce interleukin-22 at high levels which can be illustrated as a molecule which possess signal to decrease the permeability of intestinal lining.
When mice which were treated with antibiotics, exposed to peanut allergens after either colonized with Clostridia or induced with IL-22, showed lessen presence of allergens in their blood stream. Surprisingly the level of allergens amplified after the mice were induced with antibodies that mat contain the feature of neutralizing IL-22, which naturally proved the fact that Clostridia has the characteristic of preventing allergens to enter in the blood stream.
The aforesaid study has been approved by Food Allergy Research and Education and the University of Chicago which has also portrayed the fact that food allergies have infected innumerable number of populace including children in such a manner that they are suffering with sever disease which are completely untreatable.